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KMID : 0370220040480010075
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Yakhak Hoeji
2004 Volume.48 No. 1 p.75 ~ p.81
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AluI RFLP Analysis of the Calcitonin Receptor Gene in the Korean Athletic Men
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장대호/Jang DH
황영철/강병용/최성숙/강진양/하남주/wang YC/Kang BY/Choi SS/Kang CY/Ha NJ
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Abstract
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Bone mineral density (BMD) is influenced by genetic and environmental factors. Among genetic study, calcitonin receptor (CTR) gene is a good candidate influencing the inter-in dividual difference in BMD because CTR is involved in calcium and bone metabolism. Thus, we investigated the distribution of C1377T polymorphism in the CTR gene among male Korean elite athletic and control groups, respectively, and also an association with BMD in lumbar spine and femoral neck. Our results suggested that this polymorphism of CTR gene was not significantly assoclated with lumbar spine or femoral neck BMDs in the both groups, respectively. However we found that there was the racial difference in genotype distribution of this polymorphism between Caucasian and Asian populations. Though we could not detect the significant association between C1377T polymorphism of CTR gene and lumbar spine or femoral neck BMDs, further studies using other ethnic groups are necessary to clarify the precise role in BMD of CTR gene.
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KEYWORD
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